منابع مشابه
Endothelium-derived relaxing factor and coronary vasospasm.
The endothelium releases the powerful vasodilator and antiaggregatory substance, EDRF, both under basal conditions and upon stimulation by a wide variety of agents. Endothelial injury or dysfunction may play an important role in the spasmogenicity of the coronary artery, although other possible alterations related to atherosclerosis should also be considered. Among the possible stimuli, aggrega...
متن کاملHypertension, Platelets, and the Endothelium
Platelets are the smallest of the blood cells, yet they are one of the main players during the process of thrombus formation (thrombogenesis). Furthermore, the traditional belief that the endothelium exists simply to provide an inert interface between the blood and the vessel wall is no longer accurate. Indeed, the endothelium produces a large number of substances that affect blood flow and in ...
متن کاملInteraction of Platelets, Leukocytes and the Endothelium*
Interactions between the vessel wall and platelets or leukocytes were traditionally thought to be separate cellular adhesive contributions to either coagulation or inflammation. Platelets, in response to vessel wall injury, adhere to components of the extracellular matrix (ECM), which triggers sudden platelet activation and platelet plug formation. Initial responses are followed by coagulant ac...
متن کاملRole of Platelets in the Causation of Cerebral Vasospasm
J. M. RICE EDWARDS, BRIAN BULL, JOSEPH THOMPSON, and GEORGE AUSTIN (London) noted that the release of various vasoactive substances from platelets was thought to account for cerebral vasospasm after subarachnoid haemorrhage. That this was so in acute experimental vasospasm was confirmed by experiments on the cat's basilar artery in vivo. It had been shown that agents inhibiting the release phen...
متن کاملProceedings: Role of platelets in the causation of cerebral vasospasm.
J. M. RICE EDWARDS, BRIAN BULL, JOSEPH THOMPSON, and GEORGE AUSTIN (London) noted that the release of various vasoactive substances from platelets was thought to account for cerebral vasospasm after subarachnoid haemorrhage. That this was so in acute experimental vasospasm was confirmed by experiments on the cat's basilar artery in vivo. It had been shown that agents inhibiting the release phen...
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ژورنال
عنوان ژورنال: Circulation
سال: 1985
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.72.4.728